| DOI | Trouver le DOI : https://doi.org/10.1016/j.carres.2012.11.004 |
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| Auteur | Rechercher : Kubler-Kielb, J.; Rechercher : Vinogradov, E.1 |
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| Affiliation | - Conseil national de recherches du Canada
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| Format | Texte, Article |
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| Sujet | Brucella; Core part; Host-cell invasion; Human pathogens; Immune systems; Intracellular survival; Lipopolysaccharides; Low toxicity; LPS; MS; O-Antigen; Reducing ends; Spectroscopic method; Virulence factors; Nuclear magnetic resonance; Organic compounds; Structure (composition); Synthesis (chemical); Spectroscopic analysis; lipopolysaccharide; O antigen; antimicrobial activity; Brucella; chemical analysis; immune system; spectroscopy; structure analysis; Animalia; Brucella |
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| Résumé | Brucella is an animal and human pathogen that expresses several virulence factors required for host cell invasion and intracellular survival. It produces LPS with unusually low toxicity, which hampers the detection of bacteria by the host immune system and thus provides resistance against intracellular antimicrobial mechanisms of the host. By chemical and spectroscopic methods we determined the structure of the LPS core and of a non-repetitive oligosaccharide fragment at the reducing end of the O-specific polysaccharide. These data should be useful for understanding the biological role of the Brucella LPS. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved. |
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| Date de publication | 2013 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21270668 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 0630e6b2-d834-48ff-ae1a-62b437312723 |
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| Enregistrement créé | 2014-02-17 |
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| Enregistrement modifié | 2020-04-22 |
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