Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

From National Research Council Canada

Download	View accepted manuscript: Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats (PDF, 702 KB)
DOI	Resolve DOI: https://doi.org/10.1139/apnm-2016-0644
Author	Search for: Nair, Sandhya¹; Search for: Gagnon, Jacques; Search for: Pelletier, Claude; Search for: Tchoukanova, Nadia; Search for: Zhang, Junzeng¹; Search for: Ewart, H. Stephen; Search for: Ewart, Vanya; Search for: Jiao, Guangling¹; Search for: Wang, Yanwen¹
Name affiliation	National Research Council of Canada. Aquatic and Crop Resource Development
Format	Text, Article
Journal title	Applied Physiology, Nutrition, and Metabolism
ISSN	1715-5312 1715-5320
Article number	apnm-2016-0644
Pages	# of pages: 9
Subject	diet-induced obesity; glucose tolerance; insulin sensitivity; oxidative stress; inﬂammation; rat; tolérance au glucose; sensibilité insulinique; stress oxydatif; inﬂammation; rat
Abstract	Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (60 kcal% fat) and 20% fructose-drinking water were divided into four groups and treated with the dietary replacement of 0, 10% (SO10), 15% (SO15), or 20% (SO20) of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response and homeostatic model assessment-estimated insulin resistance index, decreased serum insulin, leptin and hemoglobin A1c and free fatty acids, and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.
Publication date	2017-03-31
Publisher	NRC Research Press
Language	English
Peer reviewed	Yes
NRC number	NRC-ACRD-56238
NPARC number	23001927
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Record identifier	07a747b9-4bb7-4152-a457-bb2afa385a53
Record created	2017-06-02
Record modified	2020-03-16

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Date modified:: 2020-06-02