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Spirolides isolated from Danish strains of the toxigenic dinoflagellate Alexandrium ostenfeldii

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np050220w
AuthorSearch for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1
Name affiliation
  1. National Research Council of Canada. NRC Institute for Marine Biosciences
FormatText, Article
Subjectchemistry; isolation and purification; pharmacology; imines; marine toxins; spiro compounds
Abstract
Using LC/MS methodology, spirolides were detected in two clonal isolates of Alexandrium ostenfeldii isolated from Limfjorden, Denmark. Examination of the LC/MS profiles of extracts from these Danish cultures revealed the presence of two dominant peaks representing two previously unidentified spirolide components and one minor peak identified as the previously reported desmethyl spirolide C (1). Culturing of these clonal strains, LF 37 and LF 38, of A. ostenfeldii resulted in the accumulation of sufficient cell biomass to allow for the isolation and structure elucidation of two new spirolides, 13,19-didesmethylspirolide C (2) and spirolide G (3). While 2 was found to differ from 1 only in that it contained one less methyl group, 3 was the first spirolide to be isolated that contained a 5:6:6-trispiroketal ring system. The effect of this new feature on the toxicity of 3 relative to other spirolides is presently being pursued.
Publication date
Terms of use
  • © Copyright 2006 by the American Chemical Society and the American Society of Pharmacognosy
In
  • Journal of Natural Products 69, no. 7 (8 July 2006): 983–987.
LanguageEnglish
Peer reviewedYes
NRC numberNRCC 55501
1562
NPARC number3538091
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Record identifier09c8a761-c82b-4b2a-a991-3e7ae4602329
Record created2009-03-01
Record modified2020-04-22
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