Spirolides isolated from Danish strains of the toxigenic dinoflagellate Alexandrium ostenfeldii

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np050220w
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Name affiliation
  1. National Research Council Canada. NRC Institute for Marine Biosciences
FormatText
TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
Volume69
Issue7
Pages983–987; # of pages: 5
Subjectchemistry; isolation and purification; pharmacology; imines; marine toxins; spiro compounds
Abstract
Using LC/MS methodology, spirolides were detected in two clonal isolates of Alexandrium ostenfeldii isolated from Limfjorden, Denmark. Examination of the LC/MS profiles of extracts from these Danish cultures revealed the presence of two dominant peaks representing two previously unidentified spirolide components and one minor peak identified as the previously reported desmethyl spirolide C (1). Culturing of these clonal strains, LF 37 and LF 38, of A. ostenfeldii resulted in the accumulation of sufficient cell biomass to allow for the isolation and structure elucidation of two new spirolides, 13,19-didesmethylspirolide C (2) and spirolide G (3). While 2 was found to differ from 1 only in that it contained one less methyl group, 3 was the first spirolide to be isolated that contained a 5:6:6-trispiroketal ring system. The effect of this new feature on the toxicity of 3 relative to other spirolides is presently being pursued.
Publication date
PublisherACS Publications
Terms of use
  • © Copyright 2006 by the American Chemical Society and the American Society of Pharmacognosy
LanguageEnglish
Peer reviewedYes
NRC number55501
1562
NPARC number3538091
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