| DOI | Trouver le DOI : https://doi.org/10.1021/np050220w |
|---|
| Auteur | Rechercher : MacKinnon, Shawna L.1; Rechercher : Walter, John A.1; Rechercher : Quilliam, Michael A.1; Rechercher : Cembella, Allan D.1; Rechercher : LeBlanc, Patricia1; Rechercher : Burton, Ian W.1; Rechercher : Hardstaff, William R.1; Rechercher : Lewis, Nancy I.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
|
|---|
| Format | Texte, Article |
|---|
| Sujet | chemistry; isolation and purification; pharmacology; imines; marine toxins; spiro compounds |
|---|
| Résumé | Using LC/MS methodology, spirolides were detected in two clonal isolates of Alexandrium ostenfeldii isolated from Limfjorden, Denmark. Examination of the LC/MS profiles of extracts from these Danish cultures revealed the presence of two dominant peaks representing two previously unidentified spirolide components and one minor peak identified as the previously reported desmethyl spirolide C (1). Culturing of these clonal strains, LF 37 and LF 38, of A. ostenfeldii resulted in the accumulation of sufficient cell biomass to allow for the isolation and structure elucidation of two new spirolides, 13,19-didesmethylspirolide C (2) and spirolide G (3). While 2 was found to differ from 1 only in that it contained one less methyl group, 3 was the first spirolide to be isolated that contained a 5:6:6-trispiroketal ring system. The effect of this new feature on the toxicity of 3 relative to other spirolides is presently being pursued. |
|---|
| Date de publication | 2006-07-08 |
|---|
| Conditions d’utilisation | - © Copyright 2006 by the American Chemical Society and the American Society of Pharmacognosy
|
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro du CNRC | NRCC 55501
1562 |
|---|
| Numéro NPARC | 3538091 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 09c8a761-c82b-4b2a-a991-3e7ae4602329 |
|---|
| Enregistrement créé | 2009-03-01 |
|---|
| Enregistrement modifié | 2020-04-22 |
|---|
