| Download | - View accepted manuscript: Enhanced surface plasmon resonance imaging detection of DNA hybridization on periodic gold nanoposts (PDF, 700 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1364/OL.32.003092 |
|---|
| Author | Search for: Malic, L.; Search for: Cui, B.1; Search for: Veres, T.1; Search for: Tabrizian, M. |
|---|
| Affiliation | - National Research Council of Canada. NRC Industrial Materials Institute
|
|---|
| Format | Text, Article |
|---|
| Abstract | We explore periodic gold nanoposts as substrates for the enhanced surface plasmon resonance imaging (SPRi) detection of DNA hybridization. Rigorous coupled-wave analysis was used to model and design the nanopost-based SPRi biosensor. Arrayed gold nanoposts on gold-coated glass substrate, with various widths and periodicity, were fabricated using electron-beam lithography and characterized with scanning electron and atomic force microscopy. A scanning-angle SPRi apparatus was used to conduct the kinetic analysis of DNA hybridization on nanopost-based sensor surface and assess the corresponding SPR signal amplification. Experimental results showed that both the nanostructure size and period influenced the SPR signal enhancement; the optimized 30 nm height, 50 nm size, and 110 nm period nanoposts provided a fivefold SPR signal amplification compared with the plain 50 nm thick gold film used as control. |
|---|
| Publication date | 2007-11-01 |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| NRC number | NRCC 53678 |
|---|
| NPARC number | 15854994 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 0b723396-1f7d-49b1-92b3-aa53ac685cec |
|---|
| Record created | 2010-07-30 |
|---|
| Record modified | 2020-05-10 |
|---|
