| DOI | Resolve DOI: https://doi.org/10.1166/jnn.2012.6647 |
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| Author | Search for: Hao, Yuzhi1; Search for: Song, Steven; Search for: Yang, Xiaoyan; Search for: Xing, James; Search for: Chen, Jie1 |
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| Affiliation | - National Research Council of Canada. Security and Disruptive Technologies
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| Format | Text, Article |
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| Subject | Confocal imaging; Core shell structure; Iron oxide nanoparticle; Isothiocyanates; Magnetic force; Magnetic nanoparticles; Micropores; Solution treatments; Sonication method; Spherical morphologies; Flow cytometry; Metal nanoparticles; Organic acids; Synthesis (chemical); fluorescein isothiocyanate; atomic force microscopy; confocal microscopy; fluorescence microscopy |
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| Abstract | In this article, we report a new method\-a sonication method to disperse iron oxide nanoparticles into smaller nanoparticles and make gold ions absorb onto the surface or trapped in the micropores of the iron oxide nanoparticles using sonication action. By using quick reduction of ascorbic acid and post-HCl solution treatment, gold covered magnetic nanoparticles (mGNPs) with spherical morphology and uniform size were synthesized in a water solution. The size of the mGNPs was found to be 20-30 nm. Some ideal mGNPs possessed a core-shell structure. The mGNPs were non-cytotoxic and mGNP-fluorescein isothiocyanate (FITC) can enter KG-1 cells when driven by an external magnetic force, which was confirmed by confocal imaging. The confocal image also showed the FITC inside the KG-1 cells was near the nucleus. The fluorescein isothiocyanate (FITC) delivery efficiency is about 100% according to the flow cytometry results. |
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| Publication date | 2012 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21270229 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 11c53ebf-4b5b-4e08-a29e-a9652970c616 |
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| Record created | 2014-01-14 |
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| Record modified | 2020-04-21 |
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