| DOI | Trouver le DOI : https://doi.org/10.1166/jnn.2012.6647 |
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| Auteur | Rechercher : Hao, Yuzhi1; Rechercher : Song, Steven; Rechercher : Yang, Xiaoyan; Rechercher : Xing, James; Rechercher : Chen, Jie1 |
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| Affiliation | - Conseil national de recherches du Canada. Technologies de sécurité et de rupture
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| Format | Texte, Article |
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| Sujet | Confocal imaging; Core shell structure; Iron oxide nanoparticle; Isothiocyanates; Magnetic force; Magnetic nanoparticles; Micropores; Solution treatments; Sonication method; Spherical morphologies; Flow cytometry; Metal nanoparticles; Organic acids; Synthesis (chemical); fluorescein isothiocyanate; atomic force microscopy; confocal microscopy; fluorescence microscopy |
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| Résumé | In this article, we report a new method\-a sonication method to disperse iron oxide nanoparticles into smaller nanoparticles and make gold ions absorb onto the surface or trapped in the micropores of the iron oxide nanoparticles using sonication action. By using quick reduction of ascorbic acid and post-HCl solution treatment, gold covered magnetic nanoparticles (mGNPs) with spherical morphology and uniform size were synthesized in a water solution. The size of the mGNPs was found to be 20-30 nm. Some ideal mGNPs possessed a core-shell structure. The mGNPs were non-cytotoxic and mGNP-fluorescein isothiocyanate (FITC) can enter KG-1 cells when driven by an external magnetic force, which was confirmed by confocal imaging. The confocal image also showed the FITC inside the KG-1 cells was near the nucleus. The fluorescein isothiocyanate (FITC) delivery efficiency is about 100% according to the flow cytometry results. |
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| Date de publication | 2012 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21270229 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 11c53ebf-4b5b-4e08-a29e-a9652970c616 |
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| Enregistrement créé | 2014-01-14 |
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| Enregistrement modifié | 2020-04-21 |
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