Domoic acid: a neurotoxic amino acid produced by the marine diatom Nitzschia pungens in culture

DOI	Resolve DOI: https://doi.org/10.1139/f88-241
Author	Search for: Rao, D. V. Subba; Search for: Quilliam, M. A.¹; Search for: Pocklington, R.
Name affiliation	National Research Council of Canada. NRC Institute for Marine Biosciences
Format	Text, Article
Journal title	Canadian Journal of Fisheries and Aquatic Sciences
ISSN	0706-652X 1205-7533
Volume	45
Issue	12
Pages	2076–2079
Abstract	During late 1987, an outbreak of poisoning resulting from the ingestion of cultivated blue mussels (Mytilus edulis) from a localized area in eastern Canada (Cardigan Bay, Prince Edward Island) was assocd. with massive blooms of N. pungens, a widely distributed diatom not previously known to produce toxins; human fatalities resulted. The causative agent, domoic acid, is indeed produced by this diatom. Although no domoic acid could be detected (<2 ng/mL) in culture medium prepd. from Cardigan River water, it was found in cultures of N. pungens grown in this medium at concns. ranging from 0.03 to 0.8 pg/cell in various sep. cultures harvested for chem. anal. 7-68 days after inoculation.
Publication date	1988-12
Language	English
Peer reviewed	Yes
NPARC number	23000891
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Record identifier	188ee512-748a-4cd2-8547-d6eeb2f08274
Record created	2016-11-07
Record modified	2020-03-17