| DOI | Resolve DOI: https://doi.org/10.1109/NSSMIC.2012.6551473 |
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| Author | Search for: Griffin, R. H.1; Search for: Mozenson, O.2; Search for: Beking, M.; Search for: DeRosa, M. C.; Search for: Lopinski, Gregory (Greg)3; Search for: Tarr, N. G. |
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| Affiliation | - National Research Council of Canada. Information and Communication Technologies
- National Research Council of Canada. Security and Disruptive Technologies
- National Research Council of Canada. Measurement Science and Standards
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| Format | Text, Article |
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| Conference | 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, October 29 - November 3, 2012, Anaheim, CA, USA |
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| Subject | Aptamers; Biomolecule detection; CMOS imagers; Geant4; Radiolabel; Adenosinetriphosphate; CMOS integrated circuits; Detectors; Fluorescence; Medical imaging; Nuclear physics; Radioactive tracers; Biomolecules |
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| Abstract | For the first time a CMOS imager has been used to detect the presence of radiolabeled target biomolecules captured on a functionalized surface. Using aptamer functionalization the system successfully detected 32P labeled adenosine triphosphate (ATP) at concentrations well below those typically associated with fluorescence-based sensor architectures. The system has also demonstrated its amenability to multiplexed biomolecule detection. Geant4, a Monte Carlo toolkit for simulating the passage of radiation through matter, was used to analyze the detector. Radiolabel detection offers the potential for direct quantitative measurement of bound biomolecules which is advantageous compared to the use of fluorescent tags. © 2012 IEEE. |
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| Publication date | 2012 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21270082 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 23961491-97af-4d9b-afb7-19f188a8951a |
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| Record created | 2013-12-19 |
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| Record modified | 2020-04-21 |
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