| DOI | Trouver le DOI : https://doi.org/10.1109/NSSMIC.2012.6551473 |
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| Auteur | Rechercher : Griffin, R. H.1; Rechercher : Mozenson, O.2; Rechercher : Beking, M.; Rechercher : DeRosa, M. C.; Rechercher : Lopinski, Gregory (Greg)3; Rechercher : Tarr, N. G. |
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| Affiliation | - Conseil national de recherches du Canada. Technologies de l'information et des communications
- Conseil national de recherches du Canada. Technologies de sécurité et de rupture
- Conseil national de recherches du Canada. Science des mesures et étalons
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| Format | Texte, Article |
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| Conférence | 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, October 29 - November 3, 2012, Anaheim, CA, USA |
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| Sujet | Aptamers; Biomolecule detection; CMOS imagers; Geant4; Radiolabel; Adenosinetriphosphate; CMOS integrated circuits; Detectors; Fluorescence; Medical imaging; Nuclear physics; Radioactive tracers; Biomolecules |
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| Résumé | For the first time a CMOS imager has been used to detect the presence of radiolabeled target biomolecules captured on a functionalized surface. Using aptamer functionalization the system successfully detected 32P labeled adenosine triphosphate (ATP) at concentrations well below those typically associated with fluorescence-based sensor architectures. The system has also demonstrated its amenability to multiplexed biomolecule detection. Geant4, a Monte Carlo toolkit for simulating the passage of radiation through matter, was used to analyze the detector. Radiolabel detection offers the potential for direct quantitative measurement of bound biomolecules which is advantageous compared to the use of fluorescent tags. © 2012 IEEE. |
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| Date de publication | 2012 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21270082 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 23961491-97af-4d9b-afb7-19f188a8951a |
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| Enregistrement créé | 2013-12-19 |
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| Enregistrement modifié | 2020-04-21 |
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