National Research Council of Canada. NRC Institute for Chemical Process and Environmental Technology
The structure of chlorimipramine hydrochloride was determined by the symbolic addition procedure and refined by block-diagonal least-squares to an R of 0.048 for 2569 diffractometer-measured reflexions. The dihedral angle between the aromatic-ring mean planes is 123 degrees and the tricyclic moiety has twist and skew values of 17.6 degrees and 0.66 A respectively. The dimethylaminopropyl side chain exhibits a grouche-trans rotamer which is unusual, in the solid state, for compounds of this type. Conformational parameters for the seven-membered hetero-ring in the title compound, and related tricycles, are discussed.