| Download | - View final version: Characterization and cellular toxicity studies of commercial manganese oxide nanoparticles (PDF, 5.0 MiB)
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| DOI | Resolve DOI: https://doi.org/10.3390/nano14020198 |
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| Author | Search for: Johnston, Linda J.1ORCID identifier: https://orcid.org/0000-0002-9136-4920; Search for: Du, Xiaomei2; Search for: Zborowski, Andre2; Search for: Kennedy, David C.1 |
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| Affiliation | - National Research Council of Canada. Metrology Research Centre
- National Research Council of Canada. Energy, Mining and Environment
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| Format | Text, Article |
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| Subject | nanoparticles; cytotoxicity; reactive oxygen species; transmission electron microscopy; dynamic light scattering |
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| Abstract | Manganese oxide nanoparticles (MnOₓ NPs) are finding applications in several environmentally important areas such as farming and energy storage. MnOₓ NPs span a range of metal oxidation states that open up a wide range of applications in catalysis as well. As a result, it is important to understand how such materials can impact human health through incidental exposure. In this study, we examined a range of commercially available Mn₂O₃ NPs and compared our characterization data to those supplied by manufacturers. Discrepancies were noted and then measured values were used to assess the biological impact of these materials on three mammalian cell lines—A549, HepG2 and J774A.1 cells. Cell toxicity assays showed that all Mn₂O₃ particles exhibited cytotoxic effects that may be correlated, at least in part, to the production of reactive oxygen species. All eight nanoforms also activated caspase 3 but not caspase 1, although the magnitude of these changes varied greatly between materials. |
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| Publication date | 2024-01-16 |
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| Publisher | MDPI |
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| Licence | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 2c0d34e3-857d-4953-9209-7dc978b9cb62 |
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| Record created | 2024-03-21 |
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| Record modified | 2024-03-21 |
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