| Téléchargement | - Voir la version finale : Characterization and cellular toxicity studies of commercial manganese oxide nanoparticles (PDF, 5.0 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.3390/nano14020198 |
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| Auteur | Rechercher : Johnston, Linda J.1Identifiant ORCID : https://orcid.org/0000-0002-9136-4920; Rechercher : Du, Xiaomei2; Rechercher : Zborowski, Andre2; Rechercher : Kennedy, David C.1 |
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| Affiliation | - Conseil national de recherches du Canada. Centre de recherche en métrologie
- Conseil national de recherches du Canada. Énergie, les mines et l'environnement
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| Format | Texte, Article |
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| Sujet | nanoparticles; cytotoxicity; reactive oxygen species; transmission electron microscopy; dynamic light scattering |
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| Résumé | Manganese oxide nanoparticles (MnOₓ NPs) are finding applications in several environmentally important areas such as farming and energy storage. MnOₓ NPs span a range of metal oxidation states that open up a wide range of applications in catalysis as well. As a result, it is important to understand how such materials can impact human health through incidental exposure. In this study, we examined a range of commercially available Mn₂O₃ NPs and compared our characterization data to those supplied by manufacturers. Discrepancies were noted and then measured values were used to assess the biological impact of these materials on three mammalian cell lines—A549, HepG2 and J774A.1 cells. Cell toxicity assays showed that all Mn₂O₃ particles exhibited cytotoxic effects that may be correlated, at least in part, to the production of reactive oxygen species. All eight nanoforms also activated caspase 3 but not caspase 1, although the magnitude of these changes varied greatly between materials. |
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| Date de publication | 2024-01-16 |
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| Maison d’édition | MDPI |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 2c0d34e3-857d-4953-9209-7dc978b9cb62 |
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| Enregistrement créé | 2024-03-21 |
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| Enregistrement modifié | 2024-03-21 |
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