| Download | - View accepted manuscript: Clusters of superparamagnetic iron oxide nanoparticles encapsulated in a hydrogel: a particle architecture generating a synergistic enhancement of the T2 relaxation (PDF, 747 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1021/nn2002272 |
|---|
| Author | Search for: Paquet, Chantal1; Search for: de Haan, Hendrick W.; Search for: Leek, Donald M.1; Search for: Lin, Hung-Yu2; Search for: Xiang, Bo2; Search for: Tian, Ganghong2; Search for: Kell, Arnold1; Search for: Simard, Benoit1 |
|---|
| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
- National Research Council of Canada. NRC Institute for Biodiagnostics
|
|---|
| Format | Text, Article |
|---|
| Subject | superparamagnetic iron oxide nanoparticles; transverse relaxation; contrast agent; hydrogel; pH-responsive; particle coating |
|---|
| Abstract | Clusters of iron oxide nanoparticles encapsulated in a pH-responsive hydrogel are synthesized and studied for their ability to alter the T2-relaxivity of protons. Encapsulation of the clusters with the hydrophilic coating is shown to enhance the transverse relaxation rate by up to 85% compared to clusters with no coating. With the use of pH-sensitive hydrogel, difficulties inherent in comparing particle samples are eliminated and a clear increase in relaxivity as the coating swells is demonstrated. Agreement with Monte Carlo simulations indicates that the lower diffusivity of water inside the coating and near the particle surface leads to the enhancement. This demonstration of a surface-active particle structure opens new possibilities in using similar structures for nanoparticle-based diagnostics using magnetic resonance imaging. |
|---|
| Publication date | 2011-03-23 |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| NPARC number | 19663207 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 2d58b2f4-335f-4bbf-8361-8ca890cde363 |
|---|
| Record created | 2012-03-16 |
|---|
| Record modified | 2020-04-21 |
|---|
