| Téléchargement | - Voir le manuscrit accepté : Clusters of superparamagnetic iron oxide nanoparticles encapsulated in a hydrogel: a particle architecture generating a synergistic enhancement of the T2 relaxation (PDF, 747 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/nn2002272 |
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| Auteur | Rechercher : Paquet, Chantal1; Rechercher : de Haan, Hendrick W.; Rechercher : Leek, Donald M.1; Rechercher : Lin, Hung-Yu2; Rechercher : Xiang, Bo2; Rechercher : Tian, Ganghong2; Rechercher : Kell, Arnold1; Rechercher : Simard, Benoit1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
- Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | superparamagnetic iron oxide nanoparticles; transverse relaxation; contrast agent; hydrogel; pH-responsive; particle coating |
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| Résumé | Clusters of iron oxide nanoparticles encapsulated in a pH-responsive hydrogel are synthesized and studied for their ability to alter the T2-relaxivity of protons. Encapsulation of the clusters with the hydrophilic coating is shown to enhance the transverse relaxation rate by up to 85% compared to clusters with no coating. With the use of pH-sensitive hydrogel, difficulties inherent in comparing particle samples are eliminated and a clear increase in relaxivity as the coating swells is demonstrated. Agreement with Monte Carlo simulations indicates that the lower diffusivity of water inside the coating and near the particle surface leads to the enhancement. This demonstration of a surface-active particle structure opens new possibilities in using similar structures for nanoparticle-based diagnostics using magnetic resonance imaging. |
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| Date de publication | 2011-03-23 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 19663207 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 2d58b2f4-335f-4bbf-8361-8ca890cde363 |
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| Enregistrement créé | 2012-03-16 |
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| Enregistrement modifié | 2020-04-21 |
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