| Download | - Will be available here on September 28, 2024
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| DOI | Resolve DOI: https://doi.org/10.2337/dc23-0748 |
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| Author | Search for: Li, Xiang; Search for: Shao, Xiaojian1; Search for: Kou, Minghao; Search for: Wang, Xuan; Search for: Ma, Hao; Search for: Grundberg, Elin; Search for: Bazzano, Lydia A.; Search for: Smith, Steven R.; Search for: Bray, George A.; Search for: Sacks, Frank M.; Search for: Qi, LuORCID identifier: https://orcid.org/0000-0002-8041-7791 |
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| Affiliation | - National Research Council of Canada. Digital Technologies
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| Format | Text, Article |
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| Abstract | OBJECTIVE: To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight-loss interventions with long-term changes in adiposity and body fat distribution.
RESEARCH DESIGN AND METHODS: The current study included overweight/obese participants from the POUNDS Lost trial. Blood levels of regional DNA methylation at ABCG1 were profiled by high-resolution methylC-capture sequencing at baseline among 673 participants, of whom 598 were followed up at 6 months and 543 at 2 years. Two-year changes in adiposity and computed tomography–measured body fat distribution were calculated.
RESULTS: Regional DNA methylation at ABCG1 showed significantly different associations with long-term changes in body weight and waist circumference at 6 months and 2 years in dietary interventions varying in protein intake (interaction P < 0.05 for all). Among participants assigned to an average-protein (15%) diet, lower baseline regional DNA methylation at ABCG1 was associated with greater reductions in body weight and waist circumference at 6 months and 2 years, whereas opposite associations were found among those assigned to a high-protein (25%) diet. Similar interaction patterns were also observed for body fat distribution, including visceral adipose tissue, subcutaneous adipose tissue, deep subcutaneous adipose tissue, and total adipose tissue at 6 months and 2 years (interaction P < 0.05 for all).
CONCLUSIONS: Baseline DNA methylation at ABCG1 interacted with dietary protein intake on long-term decreases in adiposity and body fat distribution. Participants with lower methylation at ABCG1 benefitted more in long-term reductions in body weight, waist circumference, and body fat distribution when consuming an average-protein diet. |
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| Publication date | 2023-09-28 |
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| Publisher | American Diabetes Association |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 31a61947-2eeb-48ec-ab17-624de0a28d9c |
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| Record created | 2023-10-30 |
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| Record modified | 2023-10-30 |
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