| Téléchargement | - Sera disponible ici le 28 septembre 2024
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| DOI | Trouver le DOI : https://doi.org/10.2337/dc23-0748 |
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| Auteur | Rechercher : Li, Xiang; Rechercher : Shao, Xiaojian1; Rechercher : Kou, Minghao; Rechercher : Wang, Xuan; Rechercher : Ma, Hao; Rechercher : Grundberg, Elin; Rechercher : Bazzano, Lydia A.; Rechercher : Smith, Steven R.; Rechercher : Bray, George A.; Rechercher : Sacks, Frank M.; Rechercher : Qi, LuIdentifiant ORCID : https://orcid.org/0000-0002-8041-7791 |
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| Affiliation | - Conseil national de recherches du Canada. Technologies numériques
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| Format | Texte, Article |
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| Résumé | OBJECTIVE: To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight-loss interventions with long-term changes in adiposity and body fat distribution.
RESEARCH DESIGN AND METHODS: The current study included overweight/obese participants from the POUNDS Lost trial. Blood levels of regional DNA methylation at ABCG1 were profiled by high-resolution methylC-capture sequencing at baseline among 673 participants, of whom 598 were followed up at 6 months and 543 at 2 years. Two-year changes in adiposity and computed tomography–measured body fat distribution were calculated.
RESULTS: Regional DNA methylation at ABCG1 showed significantly different associations with long-term changes in body weight and waist circumference at 6 months and 2 years in dietary interventions varying in protein intake (interaction P < 0.05 for all). Among participants assigned to an average-protein (15%) diet, lower baseline regional DNA methylation at ABCG1 was associated with greater reductions in body weight and waist circumference at 6 months and 2 years, whereas opposite associations were found among those assigned to a high-protein (25%) diet. Similar interaction patterns were also observed for body fat distribution, including visceral adipose tissue, subcutaneous adipose tissue, deep subcutaneous adipose tissue, and total adipose tissue at 6 months and 2 years (interaction P < 0.05 for all).
CONCLUSIONS: Baseline DNA methylation at ABCG1 interacted with dietary protein intake on long-term decreases in adiposity and body fat distribution. Participants with lower methylation at ABCG1 benefitted more in long-term reductions in body weight, waist circumference, and body fat distribution when consuming an average-protein diet. |
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| Date de publication | 2023-09-28 |
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| Maison d’édition | American Diabetes Association |
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| Dans | |
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| Complété par | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 31a61947-2eeb-48ec-ab17-624de0a28d9c |
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| Enregistrement créé | 2023-10-30 |
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| Enregistrement modifié | 2023-10-30 |
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