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Clavulanic acid inhibition of β-lactamase 1 from Bacillus cereus 569/H

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Abstract
Inactivation of beta-lactamase I by clavulanic acid was investigated. Clavulanic acid induced inhibition of the enzyme was found to be progressive with time. Benzylpenicillin provided protection against the adverse effects of the inhibitor initially, however, the enzyme was irreversibly inhibited in a progressive manner even in the presence of substrate. Reaction of beta-lactamase I with clavulanic acid, in the presence of ampicillin, led to a very rapid inactivation of the enzyme.
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  • J. Antibiot. (Tokyo) 31, no. 11 (1 November 1978): 1162–1169.
LanguageEnglish
NRC numberDURKIN1979
NPARC number9379631
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Record identifier3cd79bfd-2bda-4921-ba6e-459891439fed
Record created2009-07-10
Record modified2020-03-13
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