Clavulanic acid inhibition of β-lactamase 1 from Bacillus cereus 569/H

Auteur	Rechercher : Durkin, J. P.; Rechercher : Viswanatha, T.
Format	Texte, Article
Résumé	Inactivation of beta-lactamase I by clavulanic acid was investigated. Clavulanic acid induced inhibition of the enzyme was found to be progressive with time. Benzylpenicillin provided protection against the adverse effects of the inhibitor initially, however, the enzyme was irreversibly inhibited in a progressive manner even in the presence of substrate. Reaction of beta-lactamase I with clavulanic acid, in the presence of ampicillin, led to a very rapid inactivation of the enzyme.
Date de publication	1978-11-01
Dans	J. Antibiot. (Tokyo) 31, nº 11 (1 novembre 1978) : 1162–1169.
Langue	anglais
Numéro du CNRC	DURKIN1979
Numéro NPARC	9379631
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	3cd79bfd-2bda-4921-ba6e-459891439fed
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-03-13