| DOI | Resolve DOI: https://doi.org/10.1016/0006-291X(71)90507-9 |
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| Author | Search for: Franks, D.; Search for: Macmanus, J. |
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| Format | Text, Article |
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| Abstract | A particulate preparation of cyclic AMP phosphodiesterase from rat thymic lymphocytes exhibited two apparent Km's at 0.9×10−6M and 8.0×10−6M. The enzyme with the higher Km was stimulated by cyclic GMP by a mechanism involving an increase in the Vmax of the enzyme with no change in the Km. Cyclic GMP competitively inhibited the enzyme with the low apparent Km which had a Ki for cyclic GMP of 4×10−5M. The modulation of cyclic AMP phosphodiesterase activity by cyclic GMP in the control of cyclic AMP-mediated lymphocyte proliferation is discussed. |
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| Publication date | 1971-03-05 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | FRANKS1971 |
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| NPARC number | 9361946 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4352558c-b44c-432f-bce2-fa906c6ab764 |
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| Record created | 2009-07-10 |
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| Record modified | 2020-03-13 |
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