| DOI | Trouver le DOI : https://doi.org/10.1016/0006-291X(71)90507-9 |
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| Auteur | Rechercher : Franks, D.; Rechercher : Macmanus, J. |
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| Format | Texte, Article |
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| Résumé | A particulate preparation of cyclic AMP phosphodiesterase from rat thymic lymphocytes exhibited two apparent Km's at 0.9×10−6M and 8.0×10−6M. The enzyme with the higher Km was stimulated by cyclic GMP by a mechanism involving an increase in the Vmax of the enzyme with no change in the Km. Cyclic GMP competitively inhibited the enzyme with the low apparent Km which had a Ki for cyclic GMP of 4×10−5M. The modulation of cyclic AMP phosphodiesterase activity by cyclic GMP in the control of cyclic AMP-mediated lymphocyte proliferation is discussed. |
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| Date de publication | 1971-03-05 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | FRANKS1971 |
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| Numéro NPARC | 9361946 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 4352558c-b44c-432f-bce2-fa906c6ab764 |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-03-13 |
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