| Download | - View accepted manuscript: Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis (PDF, 948 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1351/pac200577010163 |
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| Author | Search for: Arya, P.1; Search for: Quevillon, S.1; Search for: Joseph, R.1; Search for: Wei, C.-Q.1; Search for: Gan, Z.1; Search for: Parisien, M.1; Search for: Sesmilo, E.1; Search for: Reddy, P. T.1; Search for: Chen, Z.-X.1; Search for: Durieux, P.1; Search for: Laforce, D.1; Search for: Campeau, L.-C.1; Search for: Khadem, S.1; Search for: Couve-Bonnaire, S.1; Search for: Kumar, R.1; Search for: Sharma, U.1; Search for: Leek, D. M.1; Search for: Daroszewska, M.1; Search for: Barnes, M. L.1 |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | antifungal activity; anti-inflammatory activity; aspergillosis; ICAM-1 inhibition; lignans; long-chain esters and amides; medicinal plants; neolignans; piper species |
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| Abstract | Due to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in smallmolecule chemical probes to be used as modulators of protein function. |
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| Publication date | 2005 |
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| In | |
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| Language | English |
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| Identifier | 10159745 |
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| NPARC number | 12340928 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 56f4a6cd-9d2d-4ff4-af9f-ee7684cd1285 |
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| Record created | 2009-09-11 |
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| Record modified | 2020-04-07 |
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