| Téléchargement | - Voir le manuscrit accepté : Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis (PDF, 948 Kio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.1351/pac200577010163 |
|---|
| Auteur | Rechercher : Arya, P.1; Rechercher : Quevillon, S.1; Rechercher : Joseph, R.1; Rechercher : Wei, C.-Q.1; Rechercher : Gan, Z.1; Rechercher : Parisien, M.1; Rechercher : Sesmilo, E.1; Rechercher : Reddy, P. T.1; Rechercher : Chen, Z.-X.1; Rechercher : Durieux, P.1; Rechercher : Laforce, D.1; Rechercher : Campeau, L.-C.1; Rechercher : Khadem, S.1; Rechercher : Couve-Bonnaire, S.1; Rechercher : Kumar, R.1; Rechercher : Sharma, U.1; Rechercher : Leek, D. M.1; Rechercher : Daroszewska, M.1; Rechercher : Barnes, M. L.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
|
|---|
| Format | Texte, Article |
|---|
| Sujet | antifungal activity; anti-inflammatory activity; aspergillosis; ICAM-1 inhibition; lignans; long-chain esters and amides; medicinal plants; neolignans; piper species |
|---|
| Résumé | Due to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in smallmolecule chemical probes to be used as modulators of protein function. |
|---|
| Date de publication | 2005 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Identificateur | 10159745 |
|---|
| Numéro NPARC | 12340928 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 56f4a6cd-9d2d-4ff4-af9f-ee7684cd1285 |
|---|
| Enregistrement créé | 2009-09-11 |
|---|
| Enregistrement modifié | 2020-04-07 |
|---|
