| Download | - View accepted manuscript: QASI, an international quality management dystem for CD4 T-Cell enumeration focused to make a global difference (PDF, 660 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1002/cyto.b.20487 |
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| Author | Search for: Bergeron, Michèle; Search for: Ding, Tao; Search for: Houle, Guy; Search for: Arès, Linda; Search for: Chabot, Christian; Search for: Soucy, Nadia; Search for: Seely, Peggy; Search for: Sherring, Alice; Search for: Bogdanovic, Dragica; Search for: Faucher, Sylvie; Search for: Somorjai, Ray1; Search for: Summers, Randy1; Search for: Sandstrom, Paul |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | quality management system; quality assessment program; quality assessment schemes; interlaboratory variation; quality awareness; national quality intelligence |
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| Abstract | Background: A significant worldwide mobilization effort to treat people with HIV disease began in 2003. Most guidelines for initiating antiretroviral therapy require reliable and reproducible CD4 T-cell counting. Therefore, any effort that improves global availability of quality managed assessment schemes for CD4 T-cell enumeration is a positive achievement for the clinical management of AIDS on a worldwide scale. Methods: The Canadian QASI-Quality Management System (QMS) has been in operation for over a decade. More recently, QMS has fine-tuned its strategy to optimize its global impact in the fight against the HIV/AIDS pandemic. Three modifications were implemented: (1) introduction of skills and knowledge transfer workshops pertaining to the initiation of national quality management programs for CD4 counting, (2) introduction of a road map to establish domestic EQAP for countries that are ready, and (3) introduction of a statistical analysis package which permits continuous monitoring of global impact of the QASI-QMS. Results: Based on QASI-QMS distribution of specimens over four consecutive participation cycles, there was decreased interlaboratory variation for both low and medium CD4 T-cell levels. After three cycles of consecutive participation, there is an average of 38 and 26% error reduction reported for the mid and low CD4 levels, respectively. Conclusion: The program improvements mentioned earlier appear to have had a profound effect with regard to enhancing the performance of laboratories participating in the QASI-QMS. Specifically, there is a significant reduction in interlaboratory variability of CD4 T-cell counts resulting from continuous participation in the QASI-QMS. © 2009 Clinical Cytometry Society |
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| Publication date | 2010-01-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17712967 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 66b46ced-e5b2-4b85-890f-c3acf0053773 |
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| Record created | 2011-04-09 |
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| Record modified | 2020-04-17 |
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