Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1016/j.carres.2017.08.011
Author	Search for: Sauvageau, Janelle; Search for: Bhasin, Milan; Search for: Guo, Cynthia X.; Search for: Adekoya, Itunuoluwa A.; Search for: Gray-owen, Scott D.; Search for: Oscarson, Stefan; Search for: Guazzelli, Lorenzo; Search for: Cox, Andrew
Format	Text, Article
Subject	d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP); Nuclear factor-kappa B (NF-κB); Pathogen-associated molecular pattern (PAMP); Wittig reaction; TRAF-interacting with forkhead-associated domain protein A (TIFA)
Abstract	d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that allows detection of Gram-negative bacteria by the mammalian immune system. Cellular detection of HBP depends upon its stimulation of a cascade that leads to the phosphorylation and assembly of the TRAF-interacting with forkhead-associated domain protein A (TIFA), which activates the transcription factor NF-κB. In this note, an alternate chemical synthesis of HBP is described and its biological activity is established, providing pure material for further assessing and exploiting the biological activity of this compound.
Publication date	2017-10
Publisher	Elsevier
In	Carbohydrate Research 450: 38–43.
Language	English
Peer reviewed	Yes
NPARC number	23002594
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Record identifier	6820abb9-4a39-44e6-b2eb-3508968d2d28
Record created	2017-12-05
Record modified	2020-03-16

Date modified:: 2024-07-27