Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1016/j.carres.2017.08.011
Auteur	Rechercher : Sauvageau, Janelle; Rechercher : Bhasin, Milan; Rechercher : Guo, Cynthia X.; Rechercher : Adekoya, Itunuoluwa A.; Rechercher : Gray-owen, Scott D.; Rechercher : Oscarson, Stefan; Rechercher : Guazzelli, Lorenzo; Rechercher : Cox, Andrew
Format	Texte, Article
Sujet	d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP); Nuclear factor-kappa B (NF-κB); Pathogen-associated molecular pattern (PAMP); Wittig reaction; TRAF-interacting with forkhead-associated domain protein A (TIFA)
Résumé	d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that allows detection of Gram-negative bacteria by the mammalian immune system. Cellular detection of HBP depends upon its stimulation of a cascade that leads to the phosphorylation and assembly of the TRAF-interacting with forkhead-associated domain protein A (TIFA), which activates the transcription factor NF-κB. In this note, an alternate chemical synthesis of HBP is described and its biological activity is established, providing pure material for further assessing and exploiting the biological activity of this compound.
Date de publication	2017-10
Maison d’édition	Elsevier
Dans	Carbohydrate Research 450 : 38–43.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	23002594
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	6820abb9-4a39-44e6-b2eb-3508968d2d28
Enregistrement créé	2017-12-05
Enregistrement modifié	2020-03-16

Date de modification :: 2024-07-01