| DOI | Resolve DOI: https://doi.org/10.1016/j.bbrc.2012.09.056 |
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| Author | Search for: Chakravarthy, Balu1; Search for: Gaudet, Chantal1; Search for: Ménard, Michel1; Search for: Brown, Leslie1; Search for: Atkinson, Trevor1; Search for: Laferla, Frank M.; Search for: Ito, Shingo1; Search for: Armato, Ubaldo; Search for: Dal Prà, Ilaria; Search for: Whitfield, James1 |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | Alzheimer’s disease; Dentate granule cells; Primary cilium; p75NTR; Somatostatin receptor 3 (SSTR3); 3xTg-AD mice |
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| Abstract | The hippocampal dentate gyrus is one of the two sites of continuous neurogenesis in adult rodents and humans. Virtually all dentate granule cells have a single immobile cilium with a microtubule spine or axoneme covered with a specialized cell membrane loaded with receptors such as the somatostatin receptor 3 (SSTR3), and the p75 neurotrophin receptor (p75NTR). The signals from these receptors have been reported to stimulate neuroprogenitor proliferation and the post-mitotic maturation of newborn granule cells into functioning granule cells. We have found that in 6–24-months-old triple transgenic Alzheimer’s disease model mice (3xTg-AD) producing both Aβ1-42 and the mutant human tau protein tauP301L, the dentate granule cells still had immunostainable SSTR3- and p75NTR-bearing cilia but they were only half the length of the immunostained cilia in the corresponding wild-type mice. However, the immunostainable length of the granule cell cilia was not reduced either in 2xTg-AD mice accumulating large amounts of Aβ1-42 or in mice accumulating only a mutant human tau protein. Thus it appears that a combination of Aβ1-42 and tau protein accumulation affects the levels of functionally important receptors in 3xTg-AD mice. These observations raise the important possibility that structural and functional changes in granule cell cilia might have a role in AD. |
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| Publication date | 2012-10-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S0006291X12017962 |
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| NPARC number | 21268675 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 7488c0f4-76d6-4761-9000-28d067e5efc4 |
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| Record created | 2013-11-07 |
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| Record modified | 2020-04-21 |
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