| DOI | Trouver le DOI : https://doi.org/10.1016/j.bbrc.2012.09.056 |
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| Auteur | Rechercher : Chakravarthy, Balu1; Rechercher : Gaudet, Chantal1; Rechercher : Ménard, Michel1; Rechercher : Brown, Leslie1; Rechercher : Atkinson, Trevor1; Rechercher : Laferla, Frank M.; Rechercher : Ito, Shingo1; Rechercher : Armato, Ubaldo; Rechercher : Dal Prà, Ilaria; Rechercher : Whitfield, James1 |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | Alzheimer’s disease; Dentate granule cells; Primary cilium; p75NTR; Somatostatin receptor 3 (SSTR3); 3xTg-AD mice |
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| Résumé | The hippocampal dentate gyrus is one of the two sites of continuous neurogenesis in adult rodents and humans. Virtually all dentate granule cells have a single immobile cilium with a microtubule spine or axoneme covered with a specialized cell membrane loaded with receptors such as the somatostatin receptor 3 (SSTR3), and the p75 neurotrophin receptor (p75NTR). The signals from these receptors have been reported to stimulate neuroprogenitor proliferation and the post-mitotic maturation of newborn granule cells into functioning granule cells. We have found that in 6–24-months-old triple transgenic Alzheimer’s disease model mice (3xTg-AD) producing both Aβ1-42 and the mutant human tau protein tauP301L, the dentate granule cells still had immunostainable SSTR3- and p75NTR-bearing cilia but they were only half the length of the immunostained cilia in the corresponding wild-type mice. However, the immunostainable length of the granule cell cilia was not reduced either in 2xTg-AD mice accumulating large amounts of Aβ1-42 or in mice accumulating only a mutant human tau protein. Thus it appears that a combination of Aβ1-42 and tau protein accumulation affects the levels of functionally important receptors in 3xTg-AD mice. These observations raise the important possibility that structural and functional changes in granule cell cilia might have a role in AD. |
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| Date de publication | 2012-10-01 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S0006291X12017962 |
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| Numéro NPARC | 21268675 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 7488c0f4-76d6-4761-9000-28d067e5efc4 |
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| Enregistrement créé | 2013-11-07 |
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| Enregistrement modifié | 2020-04-21 |
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