Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.1088/0026-1394/53/2/829
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  1. National Research Council Canada. Measurement Science and Standards
FormatText
TypeArticle
Journal titleMetrologia
ISSN0026-1394
1681-7575
Volume53
Issue2
Pages829–834; # of pages: 6
Abstract
The combination of isotope dilution and mass spectrometry has become an ubiquitous tool of chemical analysis. Often perceived as one of the most accurate methods of chemical analysis, it is not without shortcomings. Current isotope dilution equations are not capable of fully addressing one of the key problems encountered in chemical analysis: the possible effect of sample matrix on measured isotope ratios. The method of standard addition does compensate for the effect of sample matrix by making sure that all measured solutions have identical composition. While it is impossible to attain such condition in traditional isotope dilution, we present equations which allow for matrix-matching between all measured solutions by fusion of isotope dilution and standard addition methods.
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PublisherIOP Publishing
LanguageEnglish
Peer reviewedYes
NPARC number21277305
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