| DOI | Resolve DOI: https://doi.org/10.1016/j.bpj.2011.11.2763 |
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| Author | Search for: Pan, Jianjun; Search for: Heberle, Frederick; Search for: Kucerka, Norbert1; Search for: Tristram-Nagle, Stephanie; Search for: Szymanski, Michelle; Search for: Koepfinger, Mary; Search for: Katsaras, John |
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| Affiliation | - National Research Council of Canada. NRC Canadian Neutron Beam Centre
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| Format | Text, Article |
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| Conference | Biophysical Society 56th Annual Meeting, 25-29 February 2012, San Diego, California, USA |
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| Abstract | We have determined bilayer structural parameters of commonly used phosphatidylglycerols (PGs) in the fluid phase, by simultaneously analyzing small-angle neutron and X-ray scattering data. We report the temperature dependence of bilayer parameters obtained using the scattering density profile (SDP) model, including the area per lipid and overall bilayer thickness, as well as various intrabilayer structural parameters (e.g. hydrocarbon region thickness). Lipid areas were found to be larger than their neutral phosphatidylcholine (PC) counterparts, which is likely due to electrostatic repulsion of PG headgroups. In general, PG and PC bilayers show a similar response to changes in temperature and chain length, but a differential effect is observed with regard to chain unsaturation: the inclusion of a double bond in a PG lipid results in a smaller change in bilayer area and thickness than for the corresponding PC lipid. The extrapolated molecular area of saturated PG lipids at infinite chain length is similar to that of PC and PE, indicating the pivotal role of the glycerol-carbonyl backbone in shaping the lipid-water interface. |
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| Publication date | 2013-01-31 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21268046 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 7bda8bd7-242e-403b-a4f6-2b33cef57359 |
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| Record created | 2013-04-04 |
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| Record modified | 2020-04-22 |
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