| DOI | Trouver le DOI : https://doi.org/10.1016/j.bpj.2011.11.2763 |
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| Auteur | Rechercher : Pan, Jianjun; Rechercher : Heberle, Frederick; Rechercher : Kucerka, Norbert1; Rechercher : Tristram-Nagle, Stephanie; Rechercher : Szymanski, Michelle; Rechercher : Koepfinger, Mary; Rechercher : Katsaras, John |
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| Affiliation | - Conseil national de recherches du Canada. Centre canadien de faisceaux de neutrons du CNRC
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| Format | Texte, Article |
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| Conférence | Biophysical Society 56th Annual Meeting, 25-29 February 2012, San Diego, California, USA |
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| Résumé | We have determined bilayer structural parameters of commonly used phosphatidylglycerols (PGs) in the fluid phase, by simultaneously analyzing small-angle neutron and X-ray scattering data. We report the temperature dependence of bilayer parameters obtained using the scattering density profile (SDP) model, including the area per lipid and overall bilayer thickness, as well as various intrabilayer structural parameters (e.g. hydrocarbon region thickness). Lipid areas were found to be larger than their neutral phosphatidylcholine (PC) counterparts, which is likely due to electrostatic repulsion of PG headgroups. In general, PG and PC bilayers show a similar response to changes in temperature and chain length, but a differential effect is observed with regard to chain unsaturation: the inclusion of a double bond in a PG lipid results in a smaller change in bilayer area and thickness than for the corresponding PC lipid. The extrapolated molecular area of saturated PG lipids at infinite chain length is similar to that of PC and PE, indicating the pivotal role of the glycerol-carbonyl backbone in shaping the lipid-water interface. |
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| Date de publication | 2013-01-31 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21268046 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 7bda8bd7-242e-403b-a4f6-2b33cef57359 |
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| Enregistrement créé | 2013-04-04 |
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| Enregistrement modifié | 2020-04-22 |
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