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PH-triggered doxorubicin delivery based on hollow nanoporous silica nanoparticles with free-standing superparamagnetic Fe3O4 cores

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/jp1075498
AuthorSearch for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: ; Search for: ; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Industrial Materials Institute
FormatText, Article
SubjectAnticancer drug; Carboxylic group; Core/shell nanoparticles; Doxorubicin; Drug release; Fickian diffusion; Functionalized; Higuchi Model; Kinetics of release; Nanoporous silica; pH sensitive; Secondary amines; Silica shell; Superparamagnetics; Amides; Magnetic circuits; Nanoparticles; Superparamagnetism; Silica
Abstract
Superparamagnetic core/shell nanoparticles, composed of a free-standing Fe3O4 magnetic core inside a hollow nanoporous silica shell, have been synthesized, and their structures and magnetic and drug release behavior were systematically investigated. The hollow/nanoporous silica shells, containing secondary amine groups, were functionalized with 1, 2-cyclohexanedicarboxylic anhydride as click linkers, producing pH-sensitive amides and terminal carboxylic groups for the conjugation and release of the anticancer drug doxorubicin. The results show that the effective release occurred at pH 5 and was 3 times higher than that at pH 7.4. The kinetics of release was assumed as a Fickian diffusion process and fitted by the Higuchi model to uncover an intrinsic relationship of the released amount with time, temperature, and pH. © 2010 American Chemical Society.
Publication date
In
  • The Journal of Physical Chemistry C 115, no. 5 (2011): 1436–1443.
LanguageEnglish
Peer reviewedYes
NPARC number21271408
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Record identifier7c600e0b-06eb-4334-a96c-06ec80aa46bb
Record created2014-03-24
Record modified2020-04-21
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