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PH-triggered doxorubicin delivery based on hollow nanoporous silica nanoparticles with free-standing superparamagnetic Fe3O4 cores

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1021/jp1075498
AuteurRechercher : 1; Rechercher : 1; Rechercher : 1; Rechercher : 1; Rechercher : ; Rechercher : ; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Institut des matériaux industriels du CNRC
FormatTexte, Article
SujetAnticancer drug; Carboxylic group; Core/shell nanoparticles; Doxorubicin; Drug release; Fickian diffusion; Functionalized; Higuchi Model; Kinetics of release; Nanoporous silica; pH sensitive; Secondary amines; Silica shell; Superparamagnetics; Amides; Magnetic circuits; Nanoparticles; Superparamagnetism; Silica
Résumé
Superparamagnetic core/shell nanoparticles, composed of a free-standing Fe3O4 magnetic core inside a hollow nanoporous silica shell, have been synthesized, and their structures and magnetic and drug release behavior were systematically investigated. The hollow/nanoporous silica shells, containing secondary amine groups, were functionalized with 1, 2-cyclohexanedicarboxylic anhydride as click linkers, producing pH-sensitive amides and terminal carboxylic groups for the conjugation and release of the anticancer drug doxorubicin. The results show that the effective release occurred at pH 5 and was 3 times higher than that at pH 7.4. The kinetics of release was assumed as a Fickian diffusion process and fitted by the Higuchi model to uncover an intrinsic relationship of the released amount with time, temperature, and pH. © 2010 American Chemical Society.
Date de publication
Dans
  • The Journal of Physical Chemistry C 115, nº 5 (2011) : 1436–1443.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21271408
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Identificateur de l’enregistrement7c600e0b-06eb-4334-a96c-06ec80aa46bb
Enregistrement créé2014-03-24
Enregistrement modifié2020-04-21
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