| Download | - View accepted manuscript: A solid-phase, library synthesis of natural-product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold (PDF, 558 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1021/cc030026x |
|---|
| Author | Search for: Couve-Bonnaire, Samuel1; Search for: Chou, Doug T. H.1; Search for: Gan, Zhonghong1; Search for: Arya, Prabhat1 |
|---|
| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
|
|---|
| Format | Text, Article |
|---|
| ISSN | 1520-4766 |
|---|
| Abstract | With the goal of developing a library synthesis of tetrahydroquinoline-derived natural-product-like small molecules, a practical synthesis of enantiomerically pure tetrahydroquinoline scaffold was achieved. An asymmetric aminohydroxylation reaction was the key step in this strategy. This scaffold was further immobilized onto the solid support for the library generation. The library was obtained from three diversity sites: (i) acylation of the hydroxyl group (R₁), (ii) coupling of the Fmoc-protected amino acid to the amino group (R₂), and (iii) amidation of the N-terminal amine group (R₃). |
|---|
| Publication date | 2004 |
|---|
| In | |
|---|
| Language | English |
|---|
| Identifier | 18517171 |
|---|
| NPARC number | 12327924 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 86bfff71-810c-4b38-8c24-8cef4e496404 |
|---|
| Record created | 2009-09-10 |
|---|
| Record modified | 2020-04-17 |
|---|
