| Téléchargement | - Voir le manuscrit accepté : A solid-phase, library synthesis of natural-product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold (PDF, 558 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/cc030026x |
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| Auteur | Rechercher : Couve-Bonnaire, Samuel1; Rechercher : Chou, Doug T. H.1; Rechercher : Gan, Zhonghong1; Rechercher : Arya, Prabhat1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| ISSN | 1520-4766 |
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| Résumé | With the goal of developing a library synthesis of tetrahydroquinoline-derived natural-product-like small molecules, a practical synthesis of enantiomerically pure tetrahydroquinoline scaffold was achieved. An asymmetric aminohydroxylation reaction was the key step in this strategy. This scaffold was further immobilized onto the solid support for the library generation. The library was obtained from three diversity sites: (i) acylation of the hydroxyl group (R₁), (ii) coupling of the Fmoc-protected amino acid to the amino group (R₂), and (iii) amidation of the N-terminal amine group (R₃). |
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| Date de publication | 2004 |
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| Dans | |
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| Langue | anglais |
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| Identificateur | 18517171 |
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| Numéro NPARC | 12327924 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 86bfff71-810c-4b38-8c24-8cef4e496404 |
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| Enregistrement créé | 2009-09-10 |
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| Enregistrement modifié | 2020-04-17 |
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