| Download | - View final version: Developing hybrid polymer scaffolds using peptide modified biopolymers for cell implantation (PDF, 1.3 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/acsbiomaterials.7b00383 |
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| Author | Search for: Abraham, Sinoj1; Search for: Kuppan, Purushothaman1; Search for: Raj, Shammy1; Search for: Salama, Bassem; Search for: Korbutt, Gregory S.; Search for: Montemagno, Carlo D.1 |
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| Affiliation | - National Research Council of Canada. Nanotechnology
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| Format | Text, Article |
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| Subject | biomimics; biopolymer; subcutaneous; transplantation; vascularization |
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| Abstract | Polymeric scaffolds containing biomimics offer exciting therapies with broad potential impact for cellular therapies and thereby potentially improve success rates. Here we report the designing and fabrication of a hybrid scaffold that can prevent a foreign body reaction and maintain cell viability. A biodegradable acrylic based cross-linkable polycaprolactone based polymer was developed and using a multihead electrospinning station to fabricate hybrid scaffolds. This consists of cell growth factor mimics and factors to prevent a foreign body reaction. Transplantation studies were performed subcutaneously and in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed B6 Rag1 mice and we demonstrated extensive neo-vascularization and maintenance of islet cell viability in subcutaneously implanted neonatal porcine islet cells for up to 20 weeks of post-transplant. This novel approach for cell transplantation can improve the revascularization and allow the integration of bioactive molecules such as cell adhesion molecules, growth factors, etc. |
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| Publication date | 2017-08-28 |
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| Publisher | American Chemical Society |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23002698 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 97d4519c-52c4-406c-8f01-7bd5c45f4269 |
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| Record created | 2017-12-21 |
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| Record modified | 2020-05-30 |
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