Developing hybrid polymer scaffolds using peptide modified biopolymers for cell implantation

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.1021/acsbiomaterials.7b00383
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Name affiliation
  1. National Research Council of Canada. Nanotechnology
FormatText, Article
Subjectbiomimics; biopolymer; subcutaneous; transplantation; vascularization
Abstract
Polymeric scaffolds containing biomimics offer exciting therapies with broad potential impact for cellular therapies and thereby potentially improve success rates. Here we report the designing and fabrication of a hybrid scaffold that can prevent a foreign body reaction and maintain cell viability. A biodegradable acrylic based cross-linkable polycaprolactone based polymer was developed and using a multihead electrospinning station to fabricate hybrid scaffolds. This consists of cell growth factor mimics and factors to prevent a foreign body reaction. Transplantation studies were performed subcutaneously and in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed B6 Rag1 mice and we demonstrated extensive neo-vascularization and maintenance of islet cell viability in subcutaneously implanted neonatal porcine islet cells for up to 20 weeks of post-transplant. This novel approach for cell transplantation can improve the revascularization and allow the integration of bioactive molecules such as cell adhesion molecules, growth factors, etc.
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PublisherAmerican Chemical Society
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  • ACS Biomaterials Science & Engineering 3, no. 10: 2215–2222.
LanguageEnglish
Peer reviewedYes
NPARC number23002698
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Record identifier97d4519c-52c4-406c-8f01-7bd5c45f4269
Record created2017-12-21
Record modified2020-05-30
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