| Téléchargement | - Voir la version finale : Developing hybrid polymer scaffolds using peptide modified biopolymers for cell implantation (PDF, 1.3 Mio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.1021/acsbiomaterials.7b00383 |
|---|
| Auteur | Rechercher : Abraham, Sinoj1; Rechercher : Kuppan, Purushothaman1; Rechercher : Raj, Shammy1; Rechercher : Salama, Bassem; Rechercher : Korbutt, Gregory S.; Rechercher : Montemagno, Carlo D.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Nanotechnologie
|
|---|
| Format | Texte, Article |
|---|
| Sujet | biomimics; biopolymer; subcutaneous; transplantation; vascularization |
|---|
| Résumé | Polymeric scaffolds containing biomimics offer exciting therapies with broad potential impact for cellular therapies and thereby potentially improve success rates. Here we report the designing and fabrication of a hybrid scaffold that can prevent a foreign body reaction and maintain cell viability. A biodegradable acrylic based cross-linkable polycaprolactone based polymer was developed and using a multihead electrospinning station to fabricate hybrid scaffolds. This consists of cell growth factor mimics and factors to prevent a foreign body reaction. Transplantation studies were performed subcutaneously and in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed B6 Rag1 mice and we demonstrated extensive neo-vascularization and maintenance of islet cell viability in subcutaneously implanted neonatal porcine islet cells for up to 20 weeks of post-transplant. This novel approach for cell transplantation can improve the revascularization and allow the integration of bioactive molecules such as cell adhesion molecules, growth factors, etc. |
|---|
| Date de publication | 2017-08-28 |
|---|
| Maison d’édition | American Chemical Society |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 23002698 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 97d4519c-52c4-406c-8f01-7bd5c45f4269 |
|---|
| Enregistrement créé | 2017-12-21 |
|---|
| Enregistrement modifié | 2020-05-30 |
|---|
