| Téléchargement | - Voir la version finale : Developing hybrid polymer scaffolds using peptide modified biopolymers for cell implantation (PDF, 1.3 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/acsbiomaterials.7b00383 |
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| Auteur | Rechercher : Abraham, Sinoj1; Rechercher : Kuppan, Purushothaman1; Rechercher : Raj, Shammy1; Rechercher : Salama, Bassem; Rechercher : Korbutt, Gregory S.; Rechercher : Montemagno, Carlo D.1 |
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| Affiliation | - Conseil national de recherches Canada. Nanotechnologie
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| Format | Texte, Article |
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| Sujet | biomimics; biopolymer; subcutaneous; transplantation; vascularization |
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| Résumé | Polymeric scaffolds containing biomimics offer exciting therapies with broad potential impact for cellular therapies and thereby potentially improve success rates. Here we report the designing and fabrication of a hybrid scaffold that can prevent a foreign body reaction and maintain cell viability. A biodegradable acrylic based cross-linkable polycaprolactone based polymer was developed and using a multihead electrospinning station to fabricate hybrid scaffolds. This consists of cell growth factor mimics and factors to prevent a foreign body reaction. Transplantation studies were performed subcutaneously and in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed B6 Rag1 mice and we demonstrated extensive neo-vascularization and maintenance of islet cell viability in subcutaneously implanted neonatal porcine islet cells for up to 20 weeks of post-transplant. This novel approach for cell transplantation can improve the revascularization and allow the integration of bioactive molecules such as cell adhesion molecules, growth factors, etc. |
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| Date de publication | 2017-08-28 |
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| Maison d’édition | American Chemical Society |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23002698 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 97d4519c-52c4-406c-8f01-7bd5c45f4269 |
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| Enregistrement créé | 2017-12-21 |
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| Enregistrement modifié | 2020-05-30 |
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