| Download | - View accepted manuscript: Flow of blood-saline mixtures studied by time-domain optical coherence tomography (PDF, 823 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1117/12.808041 |
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| Author | Search for: Popescu, Dan P.1; Search for: Sowa, Michael G.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Conference | Optical Diagnostics and Sensing IX, 26 January 2009, San Jose, CA, USA |
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| Subject | time-domain optical coherence tomography; blood; light propagation; attenuation; multiple scattering of light; blood cells; blood-saline flow |
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| Abstract | In-vitro analysis of flowing blood-saline mixtures is performed by time-domain optical coherence tomography imaging. The mixtures contain blood in concentrations ranging from 100% to 20%. For each image, a corresponding compounded profile is obtained by adding one thousand adjacent A-scans. The compounded profiles are used for characterizing the optical coherence tomography signal as it propagates within the studied blood–saline mixtures. The results obtained point toward the possibility of acquiring intra-vascular images of arterial tissue that is located behind slabs of flowing blood-saline. A threshold in the propagation distance beyond which the recorded signal becomes dominated by its multiple scattered components is established along the compounded profiles. The threshold location, at a depth of ~0.6 mm, is independent of blood concentration. Further investigation of the compounded profiles reveals that the region extending to a maximum depth of about 200 μm from the point where the probing beam enters blood-saline mixtures could reveal information about the flow regime. This opens the possibility of another application for time-domain optical coherence tomography in intravascular imaging: assessing the flow regime, i.e. laminar or turbulent. |
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| Publication date | 2009-03-20 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 19703847 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | a163c8ac-764d-4cb3-8b99-be717b020868 |
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| Record created | 2012-03-28 |
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| Record modified | 2020-04-16 |
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