| Download | - View accepted manuscript: Comment on “Effect of uncontrolled factors in a validated liquid chromatography–tandem mass spectrometry method question its use as a reference method for marine toxins : major causes for concern” (PDF, 644 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/ac202361g |
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| Author | Search for: Holland, Patrick T.; Search for: McNabb, Paul; Search for: Quilliam, Michael A.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
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| Format | Text, Article |
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| Abstract | This recent paper by Otero and co-workers presents some data from analysis of okadaic acid group toxins by liquid chromatography tandem mass spectrometry (LC MS/MS) using different instruments, operating parameters, and solvent conditions. They question the suitability of this tool for quantitative analysis. This paper reveals a lack of understanding of critical factors for the successful use of LC MS methodology in general as well as some specific proficiency issues with the work reported on the three toxins. We show that there are problems with the conduct and reporting of the experiments, including possible injector carry-over and lack of quality assurance/quality control (QA/QC) controls. Therefore the specific conclusions they draw from their data are considered invalid. |
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| Publication date | 2011-10-19 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21268528 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | ade2698c-66f5-4010-8679-23d32a00dcc7 |
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| Record created | 2013-09-10 |
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| Record modified | 2020-06-04 |
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