| Téléchargement | - Voir le manuscrit accepté : Comment on “Effect of uncontrolled factors in a validated liquid chromatography–tandem mass spectrometry method question its use as a reference method for marine toxins : major causes for concern” (PDF, 644 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/ac202361g |
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| Auteur | Rechercher : Holland, Patrick T.; Rechercher : McNabb, Paul; Rechercher : Quilliam, Michael A.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
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| Format | Texte, Article |
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| Résumé | This recent paper by Otero and co-workers presents some data from analysis of okadaic acid group toxins by liquid chromatography tandem mass spectrometry (LC MS/MS) using different instruments, operating parameters, and solvent conditions. They question the suitability of this tool for quantitative analysis. This paper reveals a lack of understanding of critical factors for the successful use of LC MS methodology in general as well as some specific proficiency issues with the work reported on the three toxins. We show that there are problems with the conduct and reporting of the experiments, including possible injector carry-over and lack of quality assurance/quality control (QA/QC) controls. Therefore the specific conclusions they draw from their data are considered invalid. |
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| Date de publication | 2011-10-19 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21268528 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | ade2698c-66f5-4010-8679-23d32a00dcc7 |
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| Enregistrement créé | 2013-09-10 |
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| Enregistrement modifié | 2020-06-04 |
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