Ion channels: small molecules versus biologics: the quest for the ideal Naᵥ1.7 inhibitor

Link	https://www.drugtargetreview.com/article/6347/ion-channels-small-molecules-versus-biologics-the-quest-for-the-ideal-nav1-7-inhibitor/
Author	Search for: Perkins, Martin¹; Search for: Martina, Marzia¹
Name affiliation	National Research Council of Canada. Human Health Therapeutics
Format	Text, Article
Subject	drug targets; ion channels
Abstract	Ion channels modulate and control many fundamental physiological processes in various tissues and alterations in their functions give rise to a wide range of pathophysiologies, which makes them important drug targets. Indeed, for decades, drugs modulating ion channel activity have been targeted by the pharmaceutical industry. Historically, however, developing drugs targeting this protein class has been difficult, the most challenging aspect being the identification of an appropriate drug lead with desirable selectivity. This has been a particular issue for small molecules targeting ion channels.
Publication date	2015-09-21
Publisher	Russell Publishing Ltd.
In	Drug Target Review 2015, no. 3.
Language	English
Peer reviewed	Yes
NPARC number	23001652
Export citation	Export as RIS
Report a correction	Report a correction (opens in a new tab)
Record identifier	be35b25c-f706-4fc0-a1d6-223b31b62edf
Record created	2017-03-14
Record modified	2022-01-20