Ion channels: small molecules versus biologics: the quest for the ideal Nav1.7 inhibitor

From National Research Council Canada

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Name affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Journal titleDrug Target Review
Volume2015
Issue3
Subjectdrug targets; ion channels
Abstract
Ion channels modulate and control many fundamental physiological processes in various tissues and alterations in their functions give rise to a wide range of pathophysiologies, which makes them important drug targets. Indeed, for decades, drugs modulating ion channel activity have been targeted by the pharmaceutical industry. Historically, however, developing drugs targeting this protein class has been difficult, the most challenging aspect being the identification of an appropriate drug lead with desirable selectivity. This has been a particular issue for small molecules targeting ion channels.
Publication date
PublisherRussell Publishing Ltd.
Linkhttps://www.drugtargetreview.com/article/6347/ion-channels-small-molecules-versus-biologics-the-quest-for-the-ideal-nav1-7-inhibitor/
LanguageEnglish
Peer reviewedYes
NPARC number23001652
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