Ion channels: small molecules versus biologics: the quest for the ideal Naᵥ1.7 inhibitor

Lien	https://www.drugtargetreview.com/article/6347/ion-channels-small-molecules-versus-biologics-the-quest-for-the-ideal-nav1-7-inhibitor/
Auteur	Rechercher : Perkins, Martin¹; Rechercher : Martina, Marzia¹
Affiliation	Conseil national de recherches du Canada. Thérapeutique en santé humaine
Format	Texte, Article
Sujet	drug targets; ion channels
Résumé	Ion channels modulate and control many fundamental physiological processes in various tissues and alterations in their functions give rise to a wide range of pathophysiologies, which makes them important drug targets. Indeed, for decades, drugs modulating ion channel activity have been targeted by the pharmaceutical industry. Historically, however, developing drugs targeting this protein class has been difficult, the most challenging aspect being the identification of an appropriate drug lead with desirable selectivity. This has been a particular issue for small molecules targeting ion channels.
Date de publication	2015-09-21
Maison d’édition	Russell Publishing Ltd.
Dans	Drug Target Review 2015, nº 3.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	23001652
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	be35b25c-f706-4fc0-a1d6-223b31b62edf
Enregistrement créé	2017-03-14
Enregistrement modifié	2022-01-20