| Download | - View accepted manuscript: Discovery of Functional Genes for Systemic Acquired Resistance in Arabidopsis Thaliana through Integrated Data Mining (PDF, 1015 KiB)
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| Author | Search for: Pan, Youlian1; Search for: Pylatuik, Jeffery D.2; Search for: Ouyang, Junjun1; Search for: Famili, A. Fazel1; Search for: Fobert, Pierre R.2 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Information Technology
- National Research Council of Canada. NRC Plant Biotechnology Institute
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| Format | Text, Article |
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| Subject | integrated data mining; motif identification; classification; systemic acquired resistance; microarray |
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| Abstract | Various data mining techniques combined with sequence motif information in the promoter region of genes were applied to discover functional genes that are involved in the defense mechanism of systemic acquired resistance (SAR) in Arabidopsis thaliana. A series of K-Means clustering with difference-in-shape as distance measure was initially applied. A stability measure was used to validate this clustering process. A decision tree algorithm with the discover-and-mask technique was used to identify a group of most informative genes. Appearance and abundance of various transcription factor binding sites in the promoter region of the genes were studied. Through the combination of these techniques, we were able to identify 24 candidate genes involved in the SAR defense mechanism. The candidate genes fell into 2 highly resolved categories, each category showing significantly unique profiles of regulatory elements in their promoter regions. This study demonstrates the strength of such integration methods and suggests a broader application of this approach. |
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| Publication date | 2004 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 46550 |
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| NPARC number | 10260257 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c0821bca-4238-474d-9091-9a1d6a9c44a7 |
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| Record created | 2009-07-22 |
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| Record modified | 2020-04-17 |
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