| DOI | Resolve DOI: https://doi.org/10.1186/1471-2202-10-88 |
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| Author | Search for: Somayajulu-Nitu, Mallika; Search for: Sandhu, Jagdeep K.1; Search for: Cohen, Jerome; Search for: Sikorska, Marianna1; Search for: Sridhar, T. S.; Search for: Matei, Anca; Search for: Borowy-Borowski, Henryk1; Search for: Pandey, Siyaram |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Abstract | Background: Parkinson's disease, for which currently there is no cure, develops as a result of progressive loss of dopamine neurons in the brain; thus, identification of any potential therapeutic intervention for disease management is of a great importance. Results: Here we report that prophylactic application of water-soluble formulation of coenzyme Q₁₀ could effectively offset the effects of environmental neurotoxin paraquat, believed to be a contributing factor in the development of familial PD. In this study we utilized a model of paraquatinduced dopaminergic neurodegeneration in adult rats that received three weekly intra-peritoneal injections of the herbicide paraquat. Histological and biochemical analyses of rat brains revealed increased levels of oxidative stress markers and a loss of approximately 65% of dopamine neurons in the substantia nigra region. The paraquat-exposed rats also displayed impaired balancing skills on a slowly rotating drum (rotorod) evidenced by their reduced spontaneity in gait performance. In contrast, paraquat exposed rats receiving a water-soluble formulation of coenzyme Q₁₀ in their drinking water prior to and during the paraquat treatment neither developed neurodegeneration nor reduced rotorod performance and were indistinguishable from the control paraquat-untreated rats. Conclusion: Our data confirmed that paraquat-induced neurotoxicity represents a convenient rat model of Parkinsonian neurodegeneration suitable for mechanistic and neuroprotective studies. This is the first preclinical evaluation of a water-soluble coenzyme Q₁₀ formulation showing the evidence of prophylactic neuroprotection at clinically relevant doses. |
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| Publication date | 2009-07-27 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 15463777 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c19c6eec-0d78-4955-9e53-2f3456755855 |
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| Record created | 2010-08-16 |
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| Record modified | 2020-04-16 |
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