| DOI | Trouver le DOI : https://doi.org/10.1186/1471-2202-10-88 |
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| Auteur | Rechercher : Somayajulu-Nitu, Mallika; Rechercher : Sandhu, Jagdeep K.1; Rechercher : Cohen, Jerome; Rechercher : Sikorska, Marianna1; Rechercher : Sridhar, T. S.; Rechercher : Matei, Anca; Rechercher : Borowy-Borowski, Henryk1; Rechercher : Pandey, Siyaram |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Résumé | Background: Parkinson's disease, for which currently there is no cure, develops as a result of progressive loss of dopamine neurons in the brain; thus, identification of any potential therapeutic intervention for disease management is of a great importance. Results: Here we report that prophylactic application of water-soluble formulation of coenzyme Q₁₀ could effectively offset the effects of environmental neurotoxin paraquat, believed to be a contributing factor in the development of familial PD. In this study we utilized a model of paraquatinduced dopaminergic neurodegeneration in adult rats that received three weekly intra-peritoneal injections of the herbicide paraquat. Histological and biochemical analyses of rat brains revealed increased levels of oxidative stress markers and a loss of approximately 65% of dopamine neurons in the substantia nigra region. The paraquat-exposed rats also displayed impaired balancing skills on a slowly rotating drum (rotorod) evidenced by their reduced spontaneity in gait performance. In contrast, paraquat exposed rats receiving a water-soluble formulation of coenzyme Q₁₀ in their drinking water prior to and during the paraquat treatment neither developed neurodegeneration nor reduced rotorod performance and were indistinguishable from the control paraquat-untreated rats. Conclusion: Our data confirmed that paraquat-induced neurotoxicity represents a convenient rat model of Parkinsonian neurodegeneration suitable for mechanistic and neuroprotective studies. This is the first preclinical evaluation of a water-soluble coenzyme Q₁₀ formulation showing the evidence of prophylactic neuroprotection at clinically relevant doses. |
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| Date de publication | 2009-07-27 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 15463777 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c19c6eec-0d78-4955-9e53-2f3456755855 |
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| Enregistrement créé | 2010-08-16 |
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| Enregistrement modifié | 2020-04-16 |
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