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The antioxidant efficiency of vitamin C is concentration-dependent

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/0304-4165(86)90234-5
AuthorSearch for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada
FormatText, Article
Subjectautoxidation; vitamin C; antioxidant; plasma
Abstract
The inhibition of autoxidation of plasma lipids by vitamin C (ascorbic acid) has been studied. The ascorbate stoichiometric factor, n, i.e., the number of peroxyl radicals trapped by each ascorbate molecule, decreases as the concentration of ascorbate increases. This is attributed to the fact that ascorbate not only acts as a radical-trapping antioxidant, but can also undergo autoxidation. The data indicate that n → 2.0 as [ascorbate] → 0 and that n → 0 as [ascorbate] → ∞. This concentration-dependent behaviour accounts for the wide variation of n values reported in the literature. It is suggested that this autoxidative destruction of ascorbate may play a role regulating its concentration in blood plasma.
Publication date
PublisherElsevier
In
  • Biochimica et Biophysica Acta (BBA). General Subjects 884, no. 1: 119–123.
Noteyes
The authors were affiliated with the National Research Council of Canada, Division of Chemistry when they authored this article.
LanguageEnglish
NRC numberNRC-IRN-10307965
NPARC number12337897
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Record identifierc814f414-d4b8-4826-9798-ec63664fd7f6
Record created2009-09-10
Record modified2020-05-06
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