| DOI | Resolve DOI: https://doi.org/10.1039/c3sm50700a |
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| Author | Search for: Barrett, M.A.; Search for: Zheng, S.; Search for: Toppozini, L.A.; Search for: Alsop, R.J.; Search for: Dies, H.; Search for: Wang, A.; Search for: Jago, N.; Search for: Moore, M.; Search for: Rheinstädter, M.C.1 |
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| Affiliation | - National Research Council of Canada. NRC Canadian Neutron Beam Centre
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| Format | Text, Article |
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| Subject | Bi-layer; Cholesterol molecules; Dimyristoylphosphatidylcholine; High cholesterols; Lipid membranes; Monoclinic structures; Out-of-plane; Triclinic structures; Lipid bilayers; Molecules; X ray diffraction; Cholesterol |
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| Abstract | The molecular in-plane and out-of-plane structure of dimyristoylphosphatidylcholine (DMPC) membranes containing up to 60 mol% of cholesterol was studied using X-ray diffraction. Up to 37.5 mol% cholesterol could be dissolved in the membranes, resulting in a disordered lateral membrane structure. Highly ordered cholesterol structures were observed at cholesterol concentrations of more than 40 mol% cholesterol. These structures were characterized as immiscible cholesterol plaques, i.e., bilayers of cholesterol molecules coexisting with the lipid bilayer. The cholesterol molecules were found to form a monoclinic structure at 40 mol% cholesterol, which transformed into a triclinic arrangement at the highest concentration of 60 mol%. Monoclinic and triclinic structures were found to coexist at cholesterol concentrations between 50 and 55 mol%. © 2013 The Royal Society of Chemistry. |
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| Publication date | 2013 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21269615 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | e3083277-ccd8-427f-abe1-ef2f9cf265f5 |
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| Record created | 2013-12-13 |
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| Record modified | 2020-04-22 |
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