| DOI | Trouver le DOI : https://doi.org/10.1039/c3sm50700a |
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| Auteur | Rechercher : Barrett, M.A.; Rechercher : Zheng, S.; Rechercher : Toppozini, L.A.; Rechercher : Alsop, R.J.; Rechercher : Dies, H.; Rechercher : Wang, A.; Rechercher : Jago, N.; Rechercher : Moore, M.; Rechercher : Rheinstädter, M.C.1 |
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| Affiliation | - Conseil national de recherches du Canada. Centre canadien de faisceaux de neutrons du CNRC
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| Format | Texte, Article |
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| Sujet | Bi-layer; Cholesterol molecules; Dimyristoylphosphatidylcholine; High cholesterols; Lipid membranes; Monoclinic structures; Out-of-plane; Triclinic structures; Lipid bilayers; Molecules; X ray diffraction; Cholesterol |
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| Résumé | The molecular in-plane and out-of-plane structure of dimyristoylphosphatidylcholine (DMPC) membranes containing up to 60 mol% of cholesterol was studied using X-ray diffraction. Up to 37.5 mol% cholesterol could be dissolved in the membranes, resulting in a disordered lateral membrane structure. Highly ordered cholesterol structures were observed at cholesterol concentrations of more than 40 mol% cholesterol. These structures were characterized as immiscible cholesterol plaques, i.e., bilayers of cholesterol molecules coexisting with the lipid bilayer. The cholesterol molecules were found to form a monoclinic structure at 40 mol% cholesterol, which transformed into a triclinic arrangement at the highest concentration of 60 mol%. Monoclinic and triclinic structures were found to coexist at cholesterol concentrations between 50 and 55 mol%. © 2013 The Royal Society of Chemistry. |
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| Date de publication | 2013 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21269615 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | e3083277-ccd8-427f-abe1-ef2f9cf265f5 |
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| Enregistrement créé | 2013-12-13 |
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| Enregistrement modifié | 2020-04-22 |
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