| Download | - View final version: Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine (PDF, 4.4 MiB)
- View supplementary information part 1: Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine (DOCX, 15 KiB)
- View supplementary information part 2: Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine (DOCX, 14 KiB)
- View supplementary information part 3: Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine (JPG, 694 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1016/j.envpol.2022.119521 |
|---|
| Author | Search for: Delaval, Mathilde N.ORCID identifier: https://orcid.org/0000-0002-1340-5336; Search for: Jonsdottir, Hulda R.ORCID identifier: https://orcid.org/0000-0001-7509-5970; Search for: Leni, ZairaORCID identifier: https://orcid.org/0000-0001-6794-1727; Search for: Keller, Alejandro; Search for: Brem, Benjamin T.ORCID identifier: https://orcid.org/0000-0001-6211-2815; Search for: Siegerist, Frithjof; Search for: Schönenberger, David; Search for: Durdina, LukasORCID identifier: https://orcid.org/0000-0003-3562-879X; Search for: Elser, Miriam; Search for: Salathe, MatthiasORCID identifier: https://orcid.org/0000-0001-9092-4861; Search for: Baumlin, Nathalie; Search for: Lobo, Prem1ORCID identifier: https://orcid.org/0000-0003-0626-6646; Search for: Burtscher, Heinz; Search for: Liati, Anthi; Search for: Geiser, MarianneORCID identifier: https://orcid.org/0000-0002-4288-7995 |
|---|
| Affiliation | - National Research Council Canada. Metrology Research Centre
|
|---|
| Format | Text, Article |
|---|
| Subject | aerosol; aircraft engine exhaust; bronchial epithelial cell culture; cellular response; non-volatile particulate matter |
|---|
| Abstract | Health effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 10⁹ particles cm⁻² or 337.1 ng cm⁻². Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings. |
|---|
| Publication date | 2022-05-24 |
|---|
| Publisher | Elsevier |
|---|
| Copyright statement | - © 2022 The Authors. Published by Elsevier Ltd.
|
|---|
| Licence | |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| Identifier | S0269749122007357 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | e5990e11-625e-4abb-9718-fc398fd60afa |
|---|
| Record created | 2023-07-26 |
|---|
| Record modified | 2023-07-26 |
|---|
