Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine

Par Conseil national de recherches du Canada

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DOI	Trouver le DOI : https://doi.org/10.1016/j.envpol.2022.119521
Auteur	Rechercher : Delaval, Mathilde N.Identifiant ORCID : https://orcid.org/0000-0002-1340-5336; Rechercher : Jonsdottir, Hulda R.Identifiant ORCID : https://orcid.org/0000-0001-7509-5970; Rechercher : Leni, Zaira Identifiant ORCID : https://orcid.org/0000-0001-6794-1727; Rechercher : Keller, Alejandro; Rechercher : Brem, Benjamin T.Identifiant ORCID : https://orcid.org/0000-0001-6211-2815; Rechercher : Siegerist, Frithjof; Rechercher : Schönenberger, David; Rechercher : Durdina, Lukas Identifiant ORCID : https://orcid.org/0000-0003-3562-879X; Rechercher : Elser, Miriam; Rechercher : Salathe, Matthias Identifiant ORCID : https://orcid.org/0000-0001-9092-4861; Rechercher : Baumlin, Nathalie; Rechercher : Lobo, Prem¹Identifiant ORCID : https://orcid.org/0000-0003-0626-6646; Rechercher : Burtscher, Heinz; Rechercher : Liati, Anthi; Rechercher : Geiser, Marianne Identifiant ORCID : https://orcid.org/0000-0002-4288-7995
Affiliation	Conseil national de recherches du Canada. Centre de recherche en métrologie
Format	Texte, Article
Sujet	aerosol; aircraft engine exhaust; bronchial epithelial cell culture; cellular response; non-volatile particulate matter
Résumé	Health effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 10⁹ particles cm⁻² or 337.1 ng cm⁻². Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.
Date de publication	2022-05-24
Maison d’édition	Elsevier
Déclaration de droit d’auteur	© 2022 The Authors. Published by Elsevier Ltd.
Licence	Creative Commons, Attribution - Pas d’Utilisation Commerciale 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/deed.fr
Dans	Environmental Pollution 307, nº C, 119521 (24 mai 2022).
Langue	anglais
Publications évaluées par des pairs	Oui
Identificateur	S0269749122007357
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	e5990e11-625e-4abb-9718-fc398fd60afa
Enregistrement créé	2023-07-26
Enregistrement modifié	2023-07-26

Date de modification :: 2024-07-20